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C Peter Downes Selected Research

phosphatidylinositol 3,4,5-triphosphate

4/2010Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.
5/2004Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells.
1/2004PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal.

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C Peter Downes Research Topics

Disease

6Astrocytoma (Pilocytic Astrocytoma)
04/2011 - 01/2002
6Neoplasms (Cancer)
04/2010 - 01/2004
1Glioblastoma (Glioblastoma Multiforme)
08/2007
1Insulin Resistance
08/2006
1Obesity
06/2006
1Tuberous Sclerosis (Bourneville's Disease)
07/2004
1Carcinoma (Carcinomatosis)
07/2004

Drug/Important Bio-Agent (IBA)

8Phosphatidylinositols (Phosphatidylinositol)IBA
04/2010 - 01/2002
4PTEN Phosphohydrolase (PTEN Phosphatase)IBA
04/2010 - 01/2004
3Proteins (Proteins, Gene)FDA Link
04/2011 - 07/2004
3Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
04/2011 - 05/2004
3TensinsIBA
04/2010 - 01/2004
3phosphatidylinositol 3,4,5-triphosphateIBA
04/2010 - 01/2004
3Insulin (Novolin)FDA Link
08/2006 - 05/2004
3Type C PhospholipasesIBA
07/2004 - 01/2002
3Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA
05/2004 - 01/2002
2Phosphoric Monoester Hydrolases (Phosphatases)IBA
04/2010 - 08/2007
2LipidsIBA
04/2010 - 05/2002
2P-2 (P 2)IBA
09/2004 - 05/2002
270-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA
07/2004 - 08/2003
2Phospholipases (Phospholipase)IBA
05/2002 - 01/2002
1Phosphatidylinositol 4,5-Diphosphate (Phosphatidylinositol 4,5 Diphosphate)IBA
04/2010
1Serine (L-Serine)FDA Link
08/2006
1Insulin ReceptorIBA
08/2006
1LeptinIBA
06/2006
1Guanosine Diphosphate (GDP)IBA
09/2004
1Guanosine Triphosphate (GTP)IBA
09/2004
1Protein Kinases (Protein Kinase)IBA
07/2004
1trans-sodium crocetinate (crocetin)IBA
07/2004
1Sigma-1 ReceptorIBA
07/2004
1Hormones (Hormone)IBA
07/2004
1sigma Receptors (sigma Receptor)IBA
07/2004
1CalciumIBA
07/2004
1Insulin-Like Growth Factor I (IGF-1)IBA
05/2004
1Cholinergic ReceptorsIBA
08/2003
1Carbachol (Carbastat)FDA Link
08/2003
1Cholinergic Agents (Cholinergics)IBA
08/2003
1platelet protein P47 (pleckstrin)IBA
05/2002
1Heterotrimeric GTP-Binding Proteins (Heterotrimeric G-Proteins)IBA
01/2002
1Protein Isoforms (Isoforms)IBA
01/2002
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
01/2002